Glioblastoma Clinical Trials (2026): 272 Recruiting Interventional Studies

Last updated: March 9, 2026

Current Clinical Trial Landscape

Recruiting Trials by Treatment Stage

Newly Diagnosed GBM

Trials for patients who have not yet started or recently started standard treatment:

• Temozolomide combinations:
  • NCT03213002 - CAPTEM (Capecitabine + Temozolomide)
  • NCT06850766 - TMZ dose timing (morning vs evening)
• Immunotherapy:
  • NCT05743595 - Neoantigen DNA vaccine + Retifanlimab (PD-1)
  • NCT06805305 - DOC1021 Dendritic cell immunotherapy
• CAR-T:
  • NCT06972096 - CART-EGFR-IL13Ra2 after initial radiotherapy
• Novel approaches:
  • NCT05450744 - 131I-TLX-101 targeted radiotherapy (IPAX-2)
  • NCT05708352 - Ketogenic diet vs standard diet
  • NCT02977780 - INSIGhT platform trial (individualized therapy)

Recurrent / Progressive GBM

After progression on standard treatment:

• CAR-T therapy:
  • NCT07180927 - DLL3 CAR-T
  • NCT06814029 - IL13Ra2 CAR-T (intracranial)
  • NCT06186401 - Anti-EGFRvIII synNotch CAR
• Checkpoint inhibitors:
  • NCT06160206 - Retifanlimab + Bevacizumab + hypofractionated RT
• Local therapies:
  • NCT07145112 - LITT (laser thermal therapy) + Lomustine
  • NCT05363826 - Intracavitary photodynamic therapy
• Other novel agents:
  • NCT05226494 - Fb-PMT (novel agent)
  • NCT06649605 - 123I-ATT001 (Phase 1)

Trials by Treatment Approach

CAR-T Cell Therapy (19 trials)

CAR-T targets in GBM include EGFRvIII, IL13Ra2, HER2, GD2, and DLL3. Most are early-phase trials. View all →

Checkpoint Inhibitors (30 trials)

PD-1/PD-L1 inhibitors (pembrolizumab, nivolumab, retifanlimab) often combined with other therapies. View all →

Vaccine Therapies (12 trials)

Dendritic cell vaccines, neoantigen vaccines, and peptide vaccines aim to train the immune system against tumor cells. View all →

Tumor Treating Fields (10 trials)

TTFields (Optune) is FDA-approved for GBM. Trials test combinations with other therapies. View all →

Trial listings from ClinicalTrials.gov. Page summaries generated by AI and may contain errors. Always verify with your healthcare provider.