Waldenstrom's Macroglobulinemia Clinical Trials (2026): 32 Recruiting Interventional Studies

Last updated: March 10, 2026

Current Clinical Trial Landscape

About Waldenstrom's macroglobulinemia (WM):

WM is a rare B-cell lymphoma characterized by IgM-producing lymphoplasmacytic cells in the bone marrow. Most patients have MYD88 L265P mutation (~95%). Treatment is typically deferred until symptomatic.

Active research areas in 2026:

BTK inhibitors (14 trials): ibrutinib, zanubrutinib, next-gen agents
Rituximab combinations (7 trials)
BCL2 inhibitors (venetoclax)
CAR-T and bispecific antibodies

Standard of care: Watch & wait until symptomatic. First-line: BTK inhibitors (zanubrutinib, ibrutinib) or rituximab-based regimens (BR, R-CHOP). BTK inhibitors preferred for MYD88-mutated patients.

Recruiting Trials by Treatment Setting

First-Line (Treatment-Naive)

For patients requiring first treatment:

NCT03697356 - R-VRD (rituximab, bortezomib, lenalidomide, dex) followed by lenalidomide maintenance

Relapsed/Refractory

After progression on prior therapy:

NCT04830137 - NX-2127 (BTK degrader) for relapsed B-cell malignancies
NCT06340737 - CD22 CAR-T for recurrent/refractory disease
NCT05294731 - BGB-16673 (Bruton tyrosine kinase degrader)

Trials by Treatment Approach

BTK Inhibitors (14 trials)

BTK inhibitors are highly effective in WM, especially with MYD88 mutation. Next-generation agents and BTK degraders are being tested. View all →

Rituximab Combinations (7 trials)

Anti-CD20 antibody combinations remain important, especially for patients who cannot tolerate BTK inhibitors. View all →

BCL2 Inhibitors

Venetoclax shows activity in WM and is being studied in combinations.

CAR-T and Cellular Therapy

Emerging approaches for heavily pretreated patients.

NCT06340737 - CD22 CAR-T cells

Trial listings from ClinicalTrials.gov. Page summaries generated by AI and may contain errors. Always verify with your healthcare provider.

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