Adenoid Cystic Carcinoma Clinical Trials (2026): 17 Recruiting Interventional Studies

Last updated: March 10, 2026

Current Clinical Trial Landscape

About adenoid cystic carcinoma (ACC):

ACC is a rare cancer that most commonly arises in salivary glands but can occur in other sites. Known for slow but persistent growth with tendency for perineural invasion and late distant metastases (especially lung). NOTCH pathway mutations are common (~15-20%).

Active research areas in 2026:

NOTCH-targeted therapy (CB-103)
Carbon ion radiotherapy
Antibody-drug conjugates
Tyrosine kinase inhibitors

Standard of care: Surgery ± radiation for localized disease. Limited systemic options for metastatic ACC - no FDA-approved targeted therapies. Clinical trials are particularly important.

Recruiting Trials by Treatment Setting

Locally Advanced / Unresectable

For disease not amenable to surgery:

NCT05733910 - Carbon ion radiotherapy with simultaneous integrated boost
NCT04214366 - Carbon ion only irradiation
NCT02838602 - Carbon ions vs standard radiotherapy (randomized)

Metastatic / Recurrent

For distant or recurrent disease:

NCT05774899 - CB-103 (NOTCH inhibitor) + lenvatinib or abemaciclib for NOTCH-mutant ACC
NCT04974866 - Tyrosine kinase inhibitors in metastatic ACC
NCT04883671 - SBRT for oligometastatic ACC

Trials by Treatment Approach

NOTCH-Targeted Therapy

NOTCH pathway alterations are found in ~15-20% of ACC:

NCT05774899 - CB-103 combinations for NOTCH-mutant ACC (Phase 1/2)

Antibody-Drug Conjugates

NCT06891560 - Enfortumab vedotin (Nectin-4 ADC)
NCT06805825 - NN3201 (c-Kit ADC)
NCT05377996 - XMT-1660 (B7-H4 ADC)

Novel Targeted Agents

NCT06781567 - HG146
NCT06118086 - REM-422 for recurrent/metastatic/unresectable ACC
NCT06462183 - RGT-61159 for relapsed/refractory ACC

Immunotherapy

NCT03556228 - VMD-928 ± pembrolizumab (TrkA-overexpressing tumors)
NCT06805617 - Ivonescimab for salivary gland cancers

Carbon Ion Radiotherapy

Carbon ion therapy may be more effective than conventional radiation for radioresistant ACC:

NCT05733910 - Simultaneous integrated boost technique
NCT04214366 - Carbon ion only approach
NCT02838602 - Randomized vs standard RT

View all 17 adenoid cystic carcinoma trials on ClinicalTrials.gov →

Trial listings from ClinicalTrials.gov. Page summaries generated by AI and may contain errors. Always verify with your healthcare provider.

Find ACC Trials Matched to Your Situation

Use ClinTrialFinder's AI-powered matching to find trials based on your specific NOTCH status and treatment history.

Find Matching Trials