Colorectal Cancer Trial Landscape (August 2026)

Last updated: Aug 20, 2026 · Built by a patient who got tired of scrolling ClinicalTrials.gov

Overview

1,404
Recruiting
251
Phase 1
572
Phase 2
168
Phase 3
22
Phase 4

Active interventional trials with status RECRUITING or NOT_YET_RECRUITING. A multi-phase trial (e.g. 1/2) is counted in each of its phases.

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Mechanism Breakdown

Recruiting trials grouped by drug class. Trials with unclassifiable or non-therapeutic interventions are excluded from this view.

Checkpoint inhibitor
182
Chemotherapy
153
Other / unclassified
76
Monoclonal antibody
65
Bispecific antibody
44
Tyrosine kinase inhibitor (TKI)
30
Small-molecule inhibitor
24
Antibody-drug conjugate (ADC)
22
CAR-T cellular therapy
20
Other inhibitor
18
Vaccine (other)
13
Cereblon / IMiD modulator
9

Recently Updated Trials

NCTPhaseTitleMechanism
NCT06202183Exercise for Gut Microbiome in Patients With Young-Onset Colorectal Cancer Undergoing Chemotherapy: The COURAGE TrialUnknown mechanism
NCT06995924Improving Uptake of Surveillance in Colorectal Cancer Survivors Through Navigation and Web EducationUnknown mechanism
NCT011741212Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic CancerTumor infiltrating lymphocytes (TILs) plus PD-1 blockade -- adoptive cell therapy plus immune checkpoint inhibitor
NCT074463222FOLFIRI and Bevacizumab With or Without Pelareorep for Second-Line Treatment of Metastatic RAS-Mutated, Microsatellite-Stable Colorectal CancerVEGF -- monoclonal antibody (bevacizumab); DNA synthesis + topoisomerase I -- chemotherapy (FOLFIRI); Oncolytic virus (pelareorep)
NCT076367851, 2A Phase 1 and 2 Study of VMD-102 in Hepatocellular Carcinoma and Other Solid TumorsUnknown mechanism

Top Sponsors

SponsorRecruiting trials
Fudan University68
Sun Yat-sen University52
Sixth Affiliated Hospital, Sun Yat-sen University25
Second Affiliated Hospital, School of Medicine, Zhejiang University15
M.D. Anderson Cancer Center15

Geographic Distribution

Countries/regions with the most active trial sites for colorectal cancer. A multi-site trial is counted once per country/region.

China
489
United States
323
France
97
Italy
76
Spain
68
Canada
67
Germany
57
Netherlands
44
South Korea
39
Belgium
39

Emerging Classes

Phase-1 trials whose listed start date falls within the last 12 months — the leading edge of the field.

StartNCTTitleMechanism
Nov 1, 2026NCT07587827Study Evaluating the Safety Feasibility and Efficacy of ODI-2001 Vaccine, a Personnalized Immunotherapy in Patients With Metastatic or Locally Advanced Colon Cancer or Pancreatic CancerNeoantigens + CTLA-4 -- personalized DNA neoantigen vaccine combined with immune checkpoint blockade (anti-CTLA4 antibody)
Nov 2026NCT07738939IKS04 Regimen in Advanced Solid Tumors That Express CA242CA242 -- antibody-drug conjugate (ADC)
Oct 30, 2026NCT07272642A Phase 1, Multicenter Imaging Study of LNTH-2403 in Participants With Locally Advanced or Metastatic Solid Tumors.LRRC15 -- radiolabeled monoclonal antibody (radioimmunotherapy)
Sep 8, 2026NCT07416552A Study to Investigate CEA-PRIT 2.0 in Participants With Metastatic Colorectal Cancer (mCRC)CEA -- pretargeted radioimmunotherapy (PRIT)
Sep 1, 2026NCT07277322Neoadjuvant Dupilumab and Toripalimab in MSS CRC Subjects With Resectable Liver MetastasesIL-4Rα -- monoclonal antibody (Dupilumab); PD-1 -- immune checkpoint inhibitor (Toripalimab)
Sep 2026NCT07545122A Phase 1a/1b, First-Time-in-Human Study of CT-202, a Nectin-4 Directed Bispecific Antibody, in Participants With Recurring Triple Negative Breast, Colorectal, Urothelial CancersNectin-4 -- bispecific antibody (CT-202)
Aug 30, 2026NCT07750041A Phase Ib/II Study of SYS6090 Combination Therapy in Advanced Colorectal CancerVEGF -- monoclonal antibody (bevacizumab) combined with unknown mechanism of SYS6090
Aug 29, 2026NCT07693751A Study to Assess Safety and Efficacy of SOT109 in Patients With Advanced Unresectable or Metastatic Colorectal CancerCDH17 -- targeted biological agent

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Source: ClinicalTrials.gov, synced daily. Aggregated by ClinTrialFinder.