Last updated: Jun 27, 2026 · Built by a patient who got tired of scrolling ClinicalTrials.gov
Active interventional trials with status RECRUITING or NOT_YET_RECRUITING. A multi-phase trial (e.g. 1/2) is counted in each of its phases.
Biomarkers, stage, prior treatments — get a ranked shortlist in minutes.
Recruiting trials grouped by drug class. Trials with unclassifiable or non-therapeutic interventions are excluded from this view.
| NCT | Phase | Title | Mechanism |
|---|---|---|---|
| NCT07106034 | 2 | Standard Second-line Therapy With ONgericimab and TOripalimab in pMMR/MSS Colorectal Cancer: a Single-arm Phase II Trial | Angiogenesis + PD-1 + chemotherapy targets -- anti-VEGF + PD-1 inhibitors + chemotherapy (combination therapy) |
| NCT06412198 | 1, 2 | A Multicenter Phase 1b/2 Study of Adagrasib, Cetuximab, and Cemiplimab for Metastatic Colorectal Cancer Harboring KRAS G12C Mutations | KRAS G12C -- covalent inhibitor (Adagrasib); EGFR -- monoclonal antibody (Cetuximab); PD-1 -- immune checkpoint inhibitor (Cemiplimab) |
| NCT07630961 | 1 | Phase I Study of JFI447 [68Ga]Ga-DFC413 and Comparison to FFG233 [68Ga]Ga-NNS309 in Patients With Solid Tumors | Unknown mechanism |
| NCT07147231 | 1, 2 | Testing the Effectiveness of the Anti-cancer Drug Pidnarulex (CX-5461), in Combination With Another Anti-cancer Drug Cemiplimab (REGN2810), in Treating Refractory Microsatellite Stable Colorectal Cancer | RNA polymerase I transcription + PD-1 -- small molecule inhibitor + immune checkpoint inhibitor |
| NCT05929820 | — | Impact of Protect Your Colon™ on CRC Screening | Unknown mechanism |
| Sponsor | Recruiting trials |
|---|---|
| Fudan University | 71 |
| Sun Yat-sen University | 52 |
| Sixth Affiliated Hospital, Sun Yat-sen University | 26 |
| M.D. Anderson Cancer Center | 16 |
| Second Affiliated Hospital, School of Medicine, Zhejiang University | 15 |
Countries/regions with the most active trial sites for colorectal cancer. A multi-site trial is counted once per country/region.
Phase-1 trials whose listed start date falls within the last 12 months — the leading edge of the field.
| Start | NCT | Title | Mechanism |
|---|---|---|---|
| Dec 21, 2026 | NCT07147231 | Testing the Effectiveness of the Anti-cancer Drug Pidnarulex (CX-5461), in Combination With Another Anti-cancer Drug Cemiplimab (REGN2810), in Treating Refractory Microsatellite Stable Colorectal Cancer | RNA polymerase I transcription + PD-1 -- small molecule inhibitor + immune checkpoint inhibitor |
| Nov 1, 2026 | NCT07587827 | Study Evaluating the Safety Feasibility and Efficacy of ODI-2001 Vaccine, a Personnalized Immunotherapy in Patients With Metastatic or Locally Advanced Colon Cancer or Pancreatic Cancer | Neoantigens + CTLA-4 -- personalized DNA neoantigen vaccine combined with immune checkpoint blockade (anti-CTLA4 antibody) |
| Sep 2026 | NCT07545122 | A Phase 1a/1b, First-Time-in-Human Study of CT-202, a Nectin-4 Directed Bispecific Antibody, in Participants With Recurring Triple Negative Breast, Colorectal, Urothelial Cancers | Nectin-4 -- bispecific antibody (CT-202) |
| Aug 2026 | NCT07487168 | Safety and Efficacy of PIPAC Using Single Agent Mitomycin in Solid Tumors | DNA crosslinking -- mitomycin C (alkylating agent) |
| Jul 30, 2026 | NCT07610707 | YMN-A02 for Advanced pMMR Colorectal Cancer With Liver Metastases | CTLA-4 -- mRNA-encoded antibody (biological) |
| Jul 21, 2026 | NCT07363408 | Ivonescimab and ADG126, Alone, and in Combination With Leucovorin and Fluorouracil or FOLFIRI Regimen for the Treatment of Microsatellite Stable Advanced/Metastatic Colorectal Cancer | PD-1 + unknown target (ADG126) -- immune checkpoint blockade + unknown mechanism |
| Jul 15, 2026 | NCT07621159 | A Phase Ib/II Study of HDM2017 in Combination With Standard of Care in Advanced Colorectal Cancer | MDM2 -- small molecule inhibitor (HDM2017); VEGFR -- tyrosine kinase inhibitor (Fruquintinib) |
| Jul 2026 | NCT07594067 | TCR1188-ABC Cells in KRAS-mutated Cancers | KRAS mutant peptides -- T cell receptor (TCR) engineered T cells |
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Find My Matches →Source: ClinicalTrials.gov, synced daily. Aggregated by ClinTrialFinder.