Colorectal Cancer Trial Landscape (October 2026)

Last updated: Oct 16, 2026 · Built by a patient who got tired of scrolling ClinicalTrials.gov

Overview

1,413
Recruiting
250
Phase 1
581
Phase 2
163
Phase 3
22
Phase 4

Active interventional trials with status RECRUITING or NOT_YET_RECRUITING. A multi-phase trial (e.g. 1/2) is counted in each of its phases.

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Mechanism Breakdown

Recruiting trials grouped by drug class. Trials with unclassifiable or non-therapeutic interventions are excluded from this view.

Checkpoint inhibitor
184
Chemotherapy
146
Other / unclassified
77
Monoclonal antibody
68
Bispecific antibody
47
Tyrosine kinase inhibitor (TKI)
28
Small-molecule inhibitor
25
Antibody-drug conjugate (ADC)
23
Other inhibitor
18
CAR-T cellular therapy
18
Vaccine (other)
13
Cereblon / IMiD modulator
8

Recently Updated Trials

NCTPhaseTitleMechanism
NCT063243571, 2Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has SpreadHER2 -- tyrosine kinase inhibitor and antibody-drug conjugates
NCT068204632A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancerc-Met -- antibody-drug conjugate (ADC)
NCT073183891ASCEND-CRC: Profiling and Targeting Dynamic Tumor Resistance in Patients With Metastatic Colorectal CancerVEGF + EGFR + Chemotherapy -- targeted therapies (Bevacizumab, Cetuximab, Panitumumab) combined with chemotherapy (FOLFIRI)
NCT066054302Medical Cannabis in Patients With Advanced Pancreatic and Colorectal CancerCannabinoid receptors -- medical cannabis
NCT075940671TCR1188-ABC Cells in KRAS-mutated CancersKRAS mutant peptides -- T cell receptor (TCR) engineered T cells

Top Sponsors

SponsorRecruiting trials
Fudan University70
Sun Yat-sen University54
Sixth Affiliated Hospital, Sun Yat-sen University27
Second Affiliated Hospital, School of Medicine, Zhejiang University15
Peking University Cancer Hospital & Institute15

Geographic Distribution

Countries/regions with the most active trial sites for colorectal cancer. A multi-site trial is counted once per country/region.

China
504
United States
324
France
98
Italy
80
Spain
69
Canada
62
Germany
60
Netherlands
46
South Korea
41
Belgium
40

Emerging Classes

Phase-1 trials whose listed start date falls within the last 12 months — the leading edge of the field.

StartNCTTitleMechanism
May 6, 2027NCT07842965CCR5 Targeting Leronlimab in Combination With Hepatic Arterial Infusion Floxuridine and Systemic Therapy for the Treatment of Colorectal Cancer Liver Metastases, CHAMP TrialCCR5 -- monoclonal antibody (immune checkpoint inhibitor)
Dec 1, 2026NCT07363408Ivonescimab and ADG126, Alone, and in Combination With Leucovorin and Fluorouracil or FOLFIRI Regimen for the Treatment of Microsatellite Stable Advanced/Metastatic Colorectal CancerPD-1 + unknown target (ADG126) -- immune checkpoint blockade + unknown mechanism
Dec 2026NCT07594067TCR1188-ABC Cells in KRAS-mutated CancersKRAS mutant peptides -- T cell receptor (TCR) engineered T cells
Nov 24, 2026NCT07829588Pharmacokinetic (PK) Study of QL1203 and Vectibix® for the Treatment of RAS Wild-type Metastatic Colorectal CancerEGFR -- monoclonal antibody (anti-EGFR antibody)
Nov 1, 2026NCT07587827Study Evaluating the Safety Feasibility and Efficacy of ODI-2001 Vaccine, a Personnalized Immunotherapy in Patients With Metastatic or Locally Advanced Colon Cancer or Pancreatic CancerNeoantigens + CTLA-4 -- personalized DNA neoantigen vaccine combined with immune checkpoint blockade (anti-CTLA4 antibody)
Nov 2026NCT07738939IKS04 Regimen in Advanced Solid Tumors That Express CA242CA242 -- antibody-drug conjugate (ADC)
Oct 31, 2026NCT07859085A Study to Evaluate the Safety and Activity of GDC-7035 With Anti-Cancer Therapies in Participants With KRAS G12D-Mutated Unresectable Advanced or Metastatic Colorectal Cancer or Pancreatic Ductal AdenocarcinomaKRAS G12D -- covalent inhibitor
Oct 30, 2026NCT07272642A Phase 1, Multicenter Imaging Study of LNTH-2403 in Participants With Locally Advanced or Metastatic Solid Tumors.LRRC15 -- radiolabeled monoclonal antibody (radioimmunotherapy)

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Source: ClinicalTrials.gov, synced daily. Aggregated by ClinTrialFinder.