Multiple Myeloma Trial Landscape (June 2026)

Last updated: Jun 27, 2026 · Built by a patient who got tired of scrolling ClinicalTrials.gov

Overview

537
Recruiting
234
Phase 1
219
Phase 2
67
Phase 3
15
Phase 4

Active interventional trials with status RECRUITING or NOT_YET_RECRUITING. A multi-phase trial (e.g. 1/2) is counted in each of its phases.

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Mechanism Breakdown

Recruiting trials grouped by drug class. Trials with unclassifiable or non-therapeutic interventions are excluded from this view.

CAR-T cellular therapy
108
Cereblon / IMiD modulator
70
Bispecific antibody
69
Monoclonal antibody
25
Other / unclassified
23
Antibody-drug conjugate (ADC)
14
Proteasome inhibitor
13
Other inhibitor
12
Small-molecule inhibitor
5
CAR-NK cellular therapy
4
Vaccine (other)
4
Chemotherapy
3

Recently Updated Trials

NCTPhaseTitleMechanism
NCT069040661Autologous T Cells Transduced With Retroviral Vectors Expressing TCRs for Participant-specific Neoantigens in Patients With Hematologic MalignanciesPatient-specific neoantigen TCRs -- autologous T cell receptor (TCR) transduced T cells
NCT066154793A Study to Compare the Efficacy and Safety of BMS-986393 Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2)GPRC5D -- CAR-T cell therapy
NCT061077382Iberdomide and Daratumumab as Maintenance Therapy After an Autologous Stem Cell Transplant for Multiple MyelomaCereblon modulator + CD38 -- immunomodulation and antibody-dependent cellular cytotoxicity (IMiD + monoclonal antibody)
NCT07649681Gustabor Phase 2 - Treating Taste Changes During Cancer Therapy: A Randomized Study Evaluating an AI- Based Nutrition InterventionUnknown mechanism
NCT076712873GMMG-HD11/DSMM XXI/64007957MMY3010BCMA -- bispecific antibody (Teclistamab); CD38 -- monoclonal antibody (Daratumumab); Multiple targets including cereblon -- immunomodulatory agent (Lenalidomide); Proteasome -- proteasome inhibitor (Bortezomib); Glucocorticoid receptor -- corticosteroid (Dexamethasone)

Top Sponsors

SponsorRecruiting trials
Institute of Hematology & Blood Diseases Hospital, China24
Janssen Research & Development, LLC14
Regeneron Pharmaceuticals11
Memorial Sloan Kettering Cancer Center11
Washington University School of Medicine10

Geographic Distribution

Countries/regions with the most active trial sites for multiple myeloma. A multi-site trial is counted once per country/region.

United States
228
China
166
France
57
Spain
49
Canada
41
Australia
41
United Kingdom
39
Germany
39
Japan
31
Israel
30

Emerging Classes

Phase-1 trials whose listed start date falls within the last 12 months — the leading edge of the field.

StartNCTTitleMechanism
Jun 1, 2027NCT04579523²¹¹At-OKT10-B10 and Fludarabine Alone or in Combination With Cyclophosphamide and Low-Dose TBI Before Donor Stem Cell Transplant for the Treatment of Newly Diagnosed, Recurrent, or Refractory High-Risk Multiple MyelomaCD38 -- radioimmunotherapy (211At-OKT10-B10)
Dec 1, 2026NCT07600151Etenta-Isa-VRd in Newly Diagnosed High-Risk Multiple MyelomaCD38 -- monoclonal antibody (isatuximab); Proteasome -- proteasome inhibitor (bortezomib); Cereblon -- immunomodulatory agent (lenalidomide); Glucocorticoid receptor -- corticosteroid (dexamethasone); Unknown mechanism (etentamig)
Oct 23, 2026NCT07609706A Study of the Combination of Belantamab Mafodotin, Bortezomib, and Dexamethasone (BVd) in Participants With Multiple Myeloma and Moderate Hepatic ImpairmentBCMA -- antibody-drug conjugate (Belantamab mafodotin); Proteasome -- proteasome inhibitor (Bortezomib); Glucocorticoid receptor -- corticosteroid agonist (Dexamethasone)
Sep 1, 2026NCT07611149Study to Evaluate the Safety of UF-KURE-BCMA CAR T-Cells in Advanced MyelomaBCMA -- chimeric antigen receptor T-cell therapy (CAR T-cell)
Jul 1, 2026NCT06904066Autologous T Cells Transduced With Retroviral Vectors Expressing TCRs for Participant-specific Neoantigens in Patients With Hematologic MalignanciesPatient-specific neoantigen TCRs -- autologous T cell receptor (TCR) transduced T cells
Jul 1, 2026NCT05976555Phase I Trial of BCMA-TGF-BETA CAR-T Cells in Relapsed, Refractory MyelomaBCMA + TGF-beta -- CAR-T with TGF-beta resistance
Jul 2026NCT07479979Study of Selinexor With Carfilzomib, Isatuximab and Dexamethasone for Patients With Relapsed and/or Refractory Multiple MyelomaXPO1 -- selective inhibitor of nuclear export (selinexor); Proteasome -- proteasome inhibitor (carfilzomib); CD38 -- monoclonal antibody (isatuximab)
Jul 2026NCT07221032FT836 CAR T-cell Therapy in Combination With Daratumumab in Patients With Relapsed and/or Refractory Multiple MyelomaNKG2D -- CAR-T + CD38 -- monoclonal antibody (daratumumab)

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Source: ClinicalTrials.gov, synced daily. Aggregated by ClinTrialFinder.