Multiple Myeloma Trial Landscape (June 2026)

Last updated: Jun 9, 2026 · Built by a patient who got tired of scrolling ClinicalTrials.gov

Overview

526
Recruiting
230
Phase 1
216
Phase 2
64
Phase 3
15
Phase 4

Active interventional trials with status RECRUITING or NOT_YET_RECRUITING. A multi-phase trial (e.g. 1/2) is counted in each of its phases.

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Mechanism Breakdown

Recruiting trials grouped by drug class. Trials with unclassifiable or non-therapeutic interventions are excluded from this view.

CAR-T cellular therapy
108
Cereblon / IMiD modulator
69
Bispecific antibody
67
Monoclonal antibody
24
Other / unclassified
22
Antibody-drug conjugate (ADC)
14
Proteasome inhibitor
13
Other inhibitor
12
Small-molecule inhibitor
5
CAR-NK cellular therapy
4
Vaccine (other)
4
Chemotherapy
3

Recently Updated Trials

NCTPhaseTitleMechanism
NCT069040661Autologous T Cells Transduced With Retroviral Vectors Expressing TCRs for Participant-specific Neoantigens in Patients With Hematologic MalignanciesPatient-specific neoantigen TCRs -- autologous T cell receptor (TCR) transduced T cells
NCT056519321A Study of an MMSET Inhibitor in Patients With Relapsed and Refractory Multiple MyelomaMMSET (NSD2/WHSC1) -- small molecule inhibitor
NCT057769792Post-Transplant Maintenance Therapy With Isatuximab Plus Lenalidomide for High-Risk Multiple Myeloma PatientsCD38 -- monoclonal antibody (Isatuximab)
NCT070180502Phase II Study of QLS32015 Combination Therapy in the Treatment of Multiple MyelomaUnknown mechanism
NCT050924511, 2Phase I/II Study of CAR.70- Engineered IL15-transduced Cord Blood-derived NK Cells in Conjunction With Lymphodepleting Chemotherapy for the Management of Relapse/Refractory Hematological MalignancesCD70 -- CAR-engineered IL15-transduced natural killer (NK) cells

Top Sponsors

SponsorRecruiting trials
Institute of Hematology & Blood Diseases Hospital, China23
Janssen Research & Development, LLC13
Regeneron Pharmaceuticals12
Memorial Sloan Kettering Cancer Center11
Washington University School of Medicine10

Geographic Distribution

Countries/regions with the most active trial sites for multiple myeloma. A multi-site trial is counted once per country/region.

United States
227
China
161
France
56
Spain
48
Canada
41
Australia
40
Germany
38
United Kingdom
37
Japan
31
Israel
30

Emerging Classes

Phase-1 trials whose listed start date falls within the last 12 months — the leading edge of the field.

StartNCTTitleMechanism
Jun 1, 2027NCT04579523²¹¹At-OKT10-B10 and Fludarabine Alone or in Combination With Cyclophosphamide and Low-Dose TBI Before Donor Stem Cell Transplant for the Treatment of Newly Diagnosed, Recurrent, or Refractory High-Risk Multiple MyelomaCD38 -- radioimmunotherapy (211At-OKT10-B10)
Dec 1, 2026NCT07600151Etenta-Isa-VRd in Newly Diagnosed High-Risk Multiple MyelomaCD38 -- monoclonal antibody (isatuximab); Proteasome -- proteasome inhibitor (bortezomib); Cereblon -- immunomodulatory agent (lenalidomide); Glucocorticoid receptor -- corticosteroid (dexamethasone); Unknown mechanism (etentamig)
Oct 23, 2026NCT07609706A Study of the Combination of Belantamab Mafodotin, Bortezomib, and Dexamethasone (BVd) in Participants With Multiple Myeloma and Moderate Hepatic ImpairmentBCMA -- antibody-drug conjugate (Belantamab mafodotin); Proteasome -- proteasome inhibitor (Bortezomib); Glucocorticoid receptor -- corticosteroid agonist (Dexamethasone)
Sep 1, 2026NCT07611149Study to Evaluate the Safety of UF-KURE-BCMA CAR T-Cells in Advanced MyelomaBCMA -- chimeric antigen receptor T-cell therapy (CAR T-cell)
Jul 1, 2026NCT05976555Phase I Trial of BCMA-TGF-BETA CAR-T Cells in Relapsed, Refractory MyelomaBCMA + TGF-beta -- CAR-T with TGF-beta resistance
Jul 2026NCT07479979Study of Selinexor With Carfilzomib, Isatuximab and Dexamethasone for Patients With Relapsed and/or Refractory Multiple MyelomaXPO1 -- selective inhibitor of nuclear export (selinexor); Proteasome -- proteasome inhibitor (carfilzomib); CD38 -- monoclonal antibody (isatuximab)
Jul 2026NCT07221032FT836 CAR T-cell Therapy in Combination With Daratumumab in Patients With Relapsed and/or Refractory Multiple MyelomaNKG2D -- CAR-T + CD38 -- monoclonal antibody (daratumumab)
Jun 26, 2026NCT07463807Testing the Investigational Medication Combination of Teclistamab and Pomalidomide Compared to the Usual Treatment (Carfilzomib, Pomalidomide, and Dexamethasone) for Patients With Multiple Myeloma Who Have Relapsed Shortly After TreatmentBCMA + CD3 -- bispecific antibody (teclistamab); Cereblon modulator (pomalidomide); Proteasome inhibitor (carfilzomib)

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Source: ClinicalTrials.gov, synced daily. Aggregated by ClinTrialFinder.