Multiple Myeloma Trial Landscape (August 2026)

Last updated: Aug 20, 2026 · Built by a patient who got tired of scrolling ClinicalTrials.gov

Overview

552
Recruiting
242
Phase 1
226
Phase 2
68
Phase 3
15
Phase 4

Active interventional trials with status RECRUITING or NOT_YET_RECRUITING. A multi-phase trial (e.g. 1/2) is counted in each of its phases.

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Mechanism Breakdown

Recruiting trials grouped by drug class. Trials with unclassifiable or non-therapeutic interventions are excluded from this view.

CAR-T cellular therapy
108
Bispecific antibody
71
Cereblon / IMiD modulator
67
Monoclonal antibody
28
Other / unclassified
23
Antibody-drug conjugate (ADC)
16
Other inhibitor
14
Proteasome inhibitor
13
Small-molecule inhibitor
5
Chemotherapy
3
Kinase inhibitor (other)
3
CAR-NK cellular therapy
3

Recently Updated Trials

NCTPhaseTitleMechanism
NCT069040661Autologous T Cells Transduced With Retroviral Vectors Expressing TCRs for Participant-specific Neoantigens in Patients With Hematologic MalignanciesPatient-specific neoantigen TCRs -- autologous T cell receptor (TCR) transduced T cells
NCT057148391, 2A Study to Investigate the Safety and Efficacy of Belantamab for the Treatment of Multiple Myeloma When Used as Monotherapy and in Combination TreatmentsBCMA -- antibody-drug conjugate (Belantamab mafodotin) and unconjugated antibody
NCT04898790Improving Cognitive Function in Older Adults Undergoing Stem Cell TransplantUnknown mechanism
NCT061069451, 2AZD0305 as Monotherapy or in Combination With Anticancer Agents in Participants With Multiple MyelomaUnknown mechanism
NCT039376353Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering MyelomaCD38 -- monoclonal antibody (Daratumumab)

Top Sponsors

SponsorRecruiting trials
Institute of Hematology & Blood Diseases Hospital, China26
Janssen Research & Development, LLC12
Regeneron Pharmaceuticals11
Memorial Sloan Kettering Cancer Center11
Washington University School of Medicine10

Geographic Distribution

Countries/regions with the most active trial sites for multiple myeloma. A multi-site trial is counted once per country/region.

United States
237
China
174
France
60
Spain
52
Canada
43
Australia
43
United Kingdom
40
Germany
40
Italy
33
Japan
31

Emerging Classes

Phase-1 trials whose listed start date falls within the last 12 months — the leading edge of the field.

StartNCTTitleMechanism
Jun 1, 2027NCT04579523²¹¹At-OKT10-B10 and Fludarabine Alone or in Combination With Cyclophosphamide and Low-Dose TBI Before Donor Stem Cell Transplant for the Treatment of Newly Diagnosed, Recurrent, or Refractory High-Risk Multiple MyelomaCD38 -- radioimmunotherapy (211At-OKT10-B10)
Apr 12, 2027NCT07463807Testing the Investigational Medication Combination of Teclistamab and Pomalidomide Compared to the Usual Treatment (Carfilzomib, Pomalidomide, and Dexamethasone) for Patients With Multiple Myeloma Who Have Relapsed Shortly After TreatmentBCMA + CD3 -- bispecific antibody (teclistamab); Cereblon modulator (pomalidomide); Proteasome inhibitor (carfilzomib)
Dec 1, 2026NCT07600151Etenta-Isa-VRd in Newly Diagnosed High-Risk Multiple MyelomaCD38 -- monoclonal antibody (isatuximab); Proteasome -- proteasome inhibitor (bortezomib); Cereblon -- immunomodulatory agent (lenalidomide); Glucocorticoid receptor -- corticosteroid (dexamethasone); Unknown mechanism (etentamig)
Oct 23, 2026NCT07609706A Study of the Combination of Belantamab Mafodotin, Bortezomib, and Dexamethasone (BVd) in Participants With Multiple Myeloma and Moderate Hepatic ImpairmentBCMA -- antibody-drug conjugate (Belantamab mafodotin); Proteasome -- proteasome inhibitor (Bortezomib); Glucocorticoid receptor -- corticosteroid agonist (Dexamethasone)
Oct 16, 2026NCT07742527A Study to Evaluate the Subcutaneous Belantamab (BCMAb) Formulation Versus Intravenous Belantamab in Participants With Multiple Myeloma While Treated With Standard of CareBCMA -- antibody-drug conjugate (ADC)
Oct 2026NCT07221032FT836 CAR T-cell Therapy in Combination With Daratumumab in Patients With Relapsed and/or Refractory Multiple MyelomaNKG2D -- CAR-T + CD38 -- monoclonal antibody (daratumumab)
Sep 1, 2026NCT07611149Study to Evaluate the Safety of UF-KURE-BCMA CAR T-Cells in Advanced MyelomaBCMA -- chimeric antigen receptor T-cell therapy (CAR T-cell)
Sep 1, 2026NCT07720843TAlquetamab and BeLantamab Mafodotin in Relapsed/Refractory Multiple Myeloma (TaBleMM)GPRC5D + BCMA -- bispecific antibody (Talquetamab) + antibody-drug conjugate (Belantamab mafodotin)

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Source: ClinicalTrials.gov, synced daily. Aggregated by ClinTrialFinder.