Adrenocortical Carcinoma Clinical Trials (April 2026): 18 Recruiting Interventional Studies

Last updated: April 19, 2026

Current Clinical Trial Landscape

About adrenocortical carcinoma (ACC):

ACC is a rare and aggressive cancer of the adrenal cortex. ~1-2 cases per million per year. Often diagnosed at advanced stages. Can be functional (hormone-producing) or non-functional.

Active research areas in 2026:

Checkpoint inhibitors (pembrolizumab, dostarlimab, cemiplimab)
Targeted therapy combinations (cabozantinib, apatinib)
Mitotane combinations
Antibody-drug conjugates

Standard of care: Resectable: surgery + adjuvant mitotane. Unresectable/metastatic: mitotane + etoposide/doxorubicin/cisplatin (EDP-M). Limited second-line options.

Recruiting Trials by Treatment Setting

Adjuvant Therapy

After surgery for resectable disease:

NCT03583710 - Mitotane ± cisplatin/etoposide after surgery (Phase 3)

First-Line Metastatic

For newly diagnosed advanced disease:

NCT06831175 - PD-1 inhibitor + apatinib + mitotane

Second-Line and Beyond

After progression on mitotane-based therapy:

NCT04318730 - Camrelizumab + apatinib
NCT05563467 - Pembrolizumab monotherapy
NCT06006013 - Cabozantinib + pembrolizumab
NCT06900595 - Cabozantinib + durvalumab

Trials by Treatment Approach

Checkpoint Inhibitors

Immunotherapy trials for ACC:

NCT06333314 - Dostarlimab for locally advanced/metastatic (dMMR/MSI-H)
NCT07085572 - Cemiplimab maintenance
NCT06066333 - Radiotherapy + pembrolizumab
NCT06587802 - PD-1 antibody + radiotherapy

Targeted Therapy

NCT07189403 - DS9051b (novel agent)

Regional Therapies

NCT03127774 - HIPEC for peritoneal disease
NCT05286814 - HAIP + systemic therapy
NCT06487481 - Preoperative radiation for recurrent

Antibody-Drug Conjugates

NCT06041516 - ADCT-701 (DLK1-targeting ADC)

CAR-T Cell Therapy

NCT04897321 - B7-H3 CAR-T for pediatric solid tumors

Hormone-Based Approaches

NCT05913427 - Progesterone + standard chemotherapy

View all 18 adrenocortical carcinoma trials on ClinicalTrials.gov →

Frequently Asked Questions

How do I find adrenocortical carcinoma clinical trials?

Paste your medical summary into ClinTrialFinder to get AI-matched adrenal cancer trials in minutes. The tool considers your tumor stage, mitotane treatment history, and hormonal status.

What adrenocortical carcinoma trials are currently recruiting?

There are 18 recruiting interventional trials for adrenocortical carcinoma including immunotherapy, targeted therapies, and novel agents for adrenal cortex cancer.

Find ACC Trials Matched to Your Situation

Use ClinTrialFinder's AI-powered matching to find trials based on your specific stage and treatment history.

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