Adrenocortical Carcinoma Clinical Trials (2026): 18 Recruiting Interventional Studies

Last updated: March 10, 2026

Current Clinical Trial Landscape

About adrenocortical carcinoma (ACC):

ACC is a rare and aggressive cancer of the adrenal cortex. ~1-2 cases per million per year. Often diagnosed at advanced stages. Can be functional (hormone-producing) or non-functional.

Active research areas in 2026:

Checkpoint inhibitors (pembrolizumab, dostarlimab, cemiplimab)
Targeted therapy combinations (cabozantinib, apatinib)
Mitotane combinations
Antibody-drug conjugates

Standard of care: Resectable: surgery + adjuvant mitotane. Unresectable/metastatic: mitotane + etoposide/doxorubicin/cisplatin (EDP-M). Limited second-line options.

Recruiting Trials by Treatment Setting

Adjuvant Therapy

After surgery for resectable disease:

NCT03583710 - Mitotane ± cisplatin/etoposide after surgery (Phase 3)

First-Line Metastatic

For newly diagnosed advanced disease:

NCT06831175 - PD-1 inhibitor + apatinib + mitotane

Second-Line and Beyond

After progression on mitotane-based therapy:

NCT04318730 - Camrelizumab + apatinib
NCT05563467 - Pembrolizumab monotherapy
NCT06006013 - Cabozantinib + pembrolizumab
NCT06900595 - Cabozantinib + durvalumab

Trials by Treatment Approach

Checkpoint Inhibitors

Immunotherapy trials for ACC:

NCT06333314 - Dostarlimab for locally advanced/metastatic (dMMR/MSI-H)
NCT07085572 - Cemiplimab maintenance
NCT06066333 - Radiotherapy + pembrolizumab
NCT06587802 - PD-1 antibody + radiotherapy

Targeted Therapy

NCT07189403 - DS9051b (novel agent)

Regional Therapies

NCT03127774 - HIPEC for peritoneal disease
NCT05286814 - HAIP + systemic therapy
NCT06487481 - Preoperative radiation for recurrent

Antibody-Drug Conjugates

NCT06041516 - ADCT-701 (DLK1-targeting ADC)

CAR-T Cell Therapy

NCT04897321 - B7-H3 CAR-T for pediatric solid tumors

Hormone-Based Approaches

NCT05913427 - Progesterone + standard chemotherapy

View all 18 adrenocortical carcinoma trials on ClinicalTrials.gov →

Trial listings from ClinicalTrials.gov. Page summaries generated by AI and may contain errors. Always verify with your healthcare provider.

Find ACC Trials Matched to Your Situation

Use ClinTrialFinder's AI-powered matching to find trials based on your specific stage and treatment history.

Find Matching Trials