Ampullary Cancer Clinical Trials (2026): 12 Recruiting Interventional Studies

Last updated: March 10, 2026

Current Clinical Trial Landscape

About ampullary cancer:

Ampullary cancer arises from the ampulla of Vater where the bile duct and pancreatic duct meet the duodenum. It has better prognosis than pancreatic cancer due to earlier symptom presentation (jaundice). Can have intestinal or pancreatobiliary histology with different molecular profiles.

Active research areas in 2026:

Neoadjuvant vs upfront surgery
Immunotherapy for dMMR/MSI-H tumors
KRAS-targeted therapy
Surgical technique optimization

Standard of care: Pancreaticoduodenectomy (Whipple procedure) for resectable disease. Adjuvant chemotherapy (gemcitabine or capecitabine). For metastatic: treated similar to biliary tract cancer.

Recruiting Trials by Treatment Setting

Neoadjuvant / Resectable

Before or instead of upfront surgery:

NCT07081360 - Neoadjuvant vs upfront surgery for resectable periampullary cancer (Phase 3)
NCT06801899 - Total vs partial pancreaticoduodenectomy

Metastatic / Advanced

For unresectable or metastatic disease:

NCT06333314 - Dostarlimab for dMMR/MSI-H tumors
NCT06128551 - Elironrasib and daraxonrasib (KRAS inhibitors)
NCT07282912 - Sequential cytoreduction with standard of care

Trials by Treatment Approach

Immunotherapy

Checkpoint inhibitors for biomarker-selected patients:

NCT06333314 - Dostarlimab for dMMR/MSI-H (Phase 2)

KRAS-Targeted Therapy

KRAS mutations are common in ampullary cancer:

NCT06128551 - Elironrasib and daraxonrasib (Phase 1/2)

Targeted Therapy

NCT06760819 - Sevabertinib (FGFR inhibitor)

Surgical Approaches

NCT06801899 - Total vs partial pancreaticoduodenectomy
NCT07328607 - Laparoscopic vs open pancreaticoduodenectomy
NCT05116072 - TPIAT for resectable adenocarcinoma

Chemotherapy Optimization

NCT05780684 - Individualized 5-FU dose escalation

View all 12 ampullary cancer trials on ClinicalTrials.gov →

Trial listings from ClinicalTrials.gov. Page summaries generated by AI and may contain errors. Always verify with your healthcare provider.

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