Breast Cancer Trial Landscape (July 2026)

Last updated: Jul 11, 2026 · Built by a patient who got tired of scrolling ClinicalTrials.gov

Overview

2,291
Recruiting
326
Phase 1
807
Phase 2
266
Phase 3
63
Phase 4

Active interventional trials with status RECRUITING or NOT_YET_RECRUITING. A multi-phase trial (e.g. 1/2) is counted in each of its phases.

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Mechanism Breakdown

Recruiting trials grouped by drug class. Trials with unclassifiable or non-therapeutic interventions are excluded from this view.

Antibody-drug conjugate (ADC)
174
Checkpoint inhibitor
127
Chemotherapy
126
Hormonal / nuclear-receptor therapy
124
Other / unclassified
118
Other inhibitor
71
Kinase inhibitor (other)
54
Monoclonal antibody
43
Bispecific antibody
37
Tyrosine kinase inhibitor (TKI)
36
CAR-T cellular therapy
18
Small-molecule inhibitor
13

Recently Updated Trials

NCTPhaseTitleMechanism
NCT073575974An Open-label, Single-arm Study of Prophylaxis for Datopotamab Deruxtecan (Dato-DXd) -Related Stomatitis in Eligible Patients With Metastatic or Inoperable Locally Recurrent Breast Cancer or Locally Advanced or Metastatic Epidermal Growth Factor Receptor-Mutated Non-small Cell Lung Cancer.Trop2 -- antibody-drug conjugate (datopotamab deruxtecan) with corticosteroid prophylaxis
NCT066958452A Phase 2 Study of Zanidatamab in Patients With HER2-expressing TumorsHER2 -- bispecific antibody
NCT063121763A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)Trop2 -- antibody-drug conjugate (sacituzumab tirumotecan); PD-1 -- immune checkpoint inhibitor (pembrolizumab); chemotherapy (paclitaxel, nab-paclitaxel, capecitabine)
NCT069667003A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)Trop2 -- antibody-drug conjugate (ADC); PD-1 -- immune checkpoint inhibitor (monoclonal antibody)
NCT068413543A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)Trop-2 -- antibody-drug conjugate (sacituzumab govitecan) + PD-1 -- immune checkpoint inhibitor (pembrolizumab)

Top Sponsors

SponsorRecruiting trials
Fudan University111
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University40
Memorial Sloan Kettering Cancer Center35
Cancer Institute and Hospital, Chinese Academy of Medical Sciences30
M.D. Anderson Cancer Center29

Geographic Distribution

Countries/regions with the most active trial sites for breast cancer. A multi-site trial is counted once per country/region.

United States
719
China
613
France
163
Spain
124
Italy
123
Canada
103
South Korea
93
Germany
92
Australia
75
United Kingdom
69

Emerging Classes

Phase-1 trials whose listed start date falls within the last 12 months — the leading edge of the field.

StartNCTTitleMechanism
Oct 1, 2026NCT07553390Phase 1b Study Of TRICK-NK In Combination With T-Dxd In Treatment-Refractory Breast CancersTGFBR2 -- knockout; TROP2 -- chimeric antigen receptor (CAR) NK cells; HER2 -- antibody-drug conjugate (trastuzumab deruxtecan)
Oct 2026NCT07581314Oral Zn-Telomir Monotherapy in Patients With Advanced or Metastatic Triple-Negative Breast Cancer (TNBC)Telomerase -- inhibitor (Zn-Telomir)
Sep 15, 2026NCT06148038CBD for Breast Cancer Primary TumorsCannabinoid receptor -- cannabinoid receptor agonist (CBD)
Sep 2026NCT07545122A Phase 1a/1b, First-Time-in-Human Study of CT-202, a Nectin-4 Directed Bispecific Antibody, in Participants With Recurring Triple Negative Breast, Colorectal, Urothelial CancersNectin-4 -- bispecific antibody (CT-202)
Aug 1, 2026NCT07300475Personalized Cancer Vaccine (PCV) Strategy in Triple Negative Breast Cancer PatientsPD-1 + chemotherapy agents -- immune checkpoint inhibitor + chemotherapy
Jul 3, 2026NCT07601620A Study to Evaluate the Pharmacokinetics, Efficacy, and Safety of HLX319 vs. EU-Phesgo® in the Neoadjuvant Therapy of HER2-Positive Early or Locally Advanced Breast CancerHER2 -- monoclonal antibody (HLX319, biosimilar to Phesgo)
Jul 1, 2026NCT07494448Phase Ib/II Study of Zanidatamab Plus Tucatinib and Chemotherapy in HER2-Positive Advanced Breast CancerHER2 -- bispecific antibody plus HER2 tyrosine kinase inhibitor
Jul 2026NCT07136428Asciminib in HER2+ Breast Cancer Brain MetastasesBCR-ABL allosteric site -- allosteric inhibitor + HER2 -- monoclonal antibody

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Source: ClinicalTrials.gov, synced daily. Aggregated by ClinTrialFinder.