Breast Cancer Trial Landscape (October 2026)

Last updated: Oct 15, 2026 · Built by a patient who got tired of scrolling ClinicalTrials.gov

Overview

2,295
Recruiting
318
Phase 1
827
Phase 2
264
Phase 3
63
Phase 4

Active interventional trials with status RECRUITING or NOT_YET_RECRUITING. A multi-phase trial (e.g. 1/2) is counted in each of its phases.

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Mechanism Breakdown

Recruiting trials grouped by drug class. Trials with unclassifiable or non-therapeutic interventions are excluded from this view.

Antibody-drug conjugate (ADC)
183
Chemotherapy
126
Hormonal / nuclear-receptor therapy
124
Checkpoint inhibitor
121
Other / unclassified
110
Other inhibitor
73
Kinase inhibitor (other)
56
Monoclonal antibody
43
Tyrosine kinase inhibitor (TKI)
40
Bispecific antibody
35
Vaccine (other)
15
CAR-T cellular therapy
15

Recently Updated Trials

NCTPhaseTitleMechanism
NCT063243571, 2Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has SpreadHER2 -- tyrosine kinase inhibitor and antibody-drug conjugates
NCT064397712A Phase 2 Study to Evaluate the Efficacy, Safety and Pharmacokinetics of YL202 in Patients With BCUnknown mechanism
NCT058270813Phase IIIb Study of Ribociclib + ET in Early Breast CancerCDK4/6 -- cyclin-dependent kinase 4/6 inhibitor
NCT07140172—Axillary Radiotherapy or Axillary Lymph Node Dissection in Patients With Clinically Node- Positive Breast Cancer Undergoing Upfront Tailored Axillary SurgeryUnknown mechanism
NCT069528033A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA MutationPARP -- PARP inhibitor

Top Sponsors

SponsorRecruiting trials
Fudan University111
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University40
Memorial Sloan Kettering Cancer Center35
Cancer Institute and Hospital, Chinese Academy of Medical Sciences29
The First Affiliated Hospital with Nanjing Medical University28

Geographic Distribution

Countries/regions with the most active trial sites for breast cancer. A multi-site trial is counted once per country/region.

United States
715
China
613
France
161
Spain
123
Italy
123
Canada
100
South Korea
97
Germany
90
Australia
73
United Kingdom
67

Emerging Classes

Phase-1 trials whose listed start date falls within the last 12 months — the leading edge of the field.

StartNCTTitleMechanism
Jun 1, 2027NCT04430595Multi-4SCAR-T Therapy Targeting Breast CancerHer2 + GD2 + CD44v6 -- chimeric antigen receptor T cells (CAR-T)
Jun 2027NCT04861077Monitoring Breast Cancer Immunotherapy Treatment With Advanced Positron Emission Tomography Magnetic Resonance Imaging (PET/MRI)Tumor hypoxia -- 18F-fluoromisonidazole PET with MRI (diagnostic imaging)
Jan 2027NCT07454668Trastuzumab Deruxtecan + Stereotactic Radiosurgery (SRS) in HER2+ Breast Cancer Brain MetastasesHER2 -- antibody-drug conjugate (ADC) + stereotactic radiosurgery
Dec 15, 2026NCT07867262A Study to Evaluate the Effects of GDC-4198 in Combination With Letrozole, Fulvestrant, or Giredestrant in Participants With Locally Advanced or Metastatic Hormone Receptor-Positive, HER2-Negatve Breast CancerEstrogen receptor -- selective estrogen receptor degrader/modulator (SERD/SERM); Unknown mechanism (GDC-4198)
Dec 2026NCT07785856Study of Trastuzumab Deruxtecan (T-DXd) in Combination With a RAGE Inhibitor in Patients With T-DXd-Resistant HER2-Positive or HER2-Low Metastatic Breast CancerHER2 + RAGE -- antibody-drug conjugate (T-DXd) combined with RAGE inhibitor
Nov 2026NCT07730125Gene-edited T Regulatory Cells (CRG-150) for the Treatment of Relapsed/Refractory MalignanciesRegulatory T cells -- gene-edited cell therapy
Oct 30, 2026NCT07272642A Phase 1, Multicenter Imaging Study of LNTH-2403 in Participants With Locally Advanced or Metastatic Solid Tumors.LRRC15 -- radiolabeled monoclonal antibody (radioimmunotherapy)
Oct 30, 2026NCT07310420A Trial to Evaluate Ovarian Suppression Following Subcutaneous ZOLADEX 10.8 mg in Premenopausal Women With Early-stage and Advanced HR+ Breast CancerGnRH receptor -- ovarian suppression via luteinizing hormone release inhibition (GnRH agonist)

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Source: ClinicalTrials.gov, synced daily. Aggregated by ClinTrialFinder.