Breast Cancer Trial Landscape (August 2026)

Last updated: Aug 26, 2026 · Built by a patient who got tired of scrolling ClinicalTrials.gov

Overview

2,323
Recruiting
331
Phase 1
826
Phase 2
263
Phase 3
64
Phase 4

Active interventional trials with status RECRUITING or NOT_YET_RECRUITING. A multi-phase trial (e.g. 1/2) is counted in each of its phases.

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Mechanism Breakdown

Recruiting trials grouped by drug class. Trials with unclassifiable or non-therapeutic interventions are excluded from this view.

Antibody-drug conjugate (ADC)
180
Chemotherapy
130
Hormonal / nuclear-receptor therapy
124
Checkpoint inhibitor
124
Other / unclassified
118
Other inhibitor
73
Kinase inhibitor (other)
54
Monoclonal antibody
43
Tyrosine kinase inhibitor (TKI)
39
Bispecific antibody
36
CAR-T cellular therapy
17
Vaccine (other)
15

Recently Updated Trials

NCTPhaseTitleMechanism
NCT071023812A Phase 2 Neoadjuvant Study of Zanidatamab in Combination With Chemotherapy in Participants With HER2-positive Breast CancerHER2 -- bispecific antibody
NCT058270813Phase IIIb Study of Ribociclib + ET in Early Breast CancerCDK4/6 -- cyclin-dependent kinase 4/6 inhibitor
NCT058942393A Study to Evaluate the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combination With Phesgo in Participants With PIK3CA-Mutated HER2-Positive Locally Advanced or Metastatic Breast CancerPI3K + HER2 -- PI3K inhibitor + anti-HER2 antibody combination
NCT065456821Phase Ib Study of AlpeliSib With PEmbroLizumab in Patients With mEtastatic Breast caNcer or melanomA (SELENA)PI3K alpha + PD-1 -- PI3K alpha inhibitor + immune checkpoint inhibitor
NCT060675032Biomarkers to Detect Endocrine Therapy ResistanceUnknown mechanism

Top Sponsors

SponsorRecruiting trials
Fudan University110
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University39
Memorial Sloan Kettering Cancer Center36
Cancer Institute and Hospital, Chinese Academy of Medical Sciences29
The First Affiliated Hospital with Nanjing Medical University28

Geographic Distribution

Countries/regions with the most active trial sites for breast cancer. A multi-site trial is counted once per country/region.

United States
728
China
613
France
158
Spain
123
Italy
123
Canada
101
South Korea
94
Germany
91
Australia
74
United Kingdom
68

Emerging Classes

Phase-1 trials whose listed start date falls within the last 12 months — the leading edge of the field.

StartNCTTitleMechanism
Jun 2027NCT04861077Monitoring Breast Cancer Immunotherapy Treatment With Advanced Positron Emission Tomography Magnetic Resonance Imaging (PET/MRI)Tumor hypoxia -- 18F-fluoromisonidazole PET with MRI (diagnostic imaging)
Dec 2026NCT07785856Study of Trastuzumab Deruxtecan (T-DXd) in Combination With a RAGE Inhibitor in Patients With T-DXd-Resistant HER2-Positive or HER2-Low Metastatic Breast CancerHER2 + RAGE -- antibody-drug conjugate (T-DXd) combined with RAGE inhibitor
Nov 2026NCT07730125Gene-edited T Regulatory Cells (CRG-150) for the Treatment of Relapsed/Refractory MalignanciesRegulatory T cells -- gene-edited cell therapy
Oct 30, 2026NCT07272642A Phase 1, Multicenter Imaging Study of LNTH-2403 in Participants With Locally Advanced or Metastatic Solid Tumors.LRRC15 -- radiolabeled monoclonal antibody (radioimmunotherapy)
Oct 1, 2026NCT07553390Phase 1b Study Of TRICK-NK In Combination With T-Dxd In Treatment-Refractory Breast CancersTGFBR2 -- knockout; TROP2 -- chimeric antigen receptor (CAR) NK cells; HER2 -- antibody-drug conjugate (trastuzumab deruxtecan)
Oct 2026NCT07581314Oral Zn-Telomir Monotherapy in Patients With Advanced or Metastatic Triple-Negative Breast Cancer (TNBC)Telomerase -- inhibitor (Zn-Telomir)
Sep 15, 2026NCT06148038CBD for Breast Cancer Primary TumorsCannabinoid receptor -- cannabinoid receptor agonist (CBD)
Sep 2026NCT07545122A Phase 1a/1b, First-Time-in-Human Study of CT-202, a Nectin-4 Directed Bispecific Antibody, in Participants With Recurring Triple Negative Breast, Colorectal, Urothelial CancersNectin-4 -- bispecific antibody (CT-202)

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Source: ClinicalTrials.gov, synced daily. Aggregated by ClinTrialFinder.