Hepatocellular Carcinoma Trial Landscape (June 2026)

Last updated: Jun 9, 2026 · Built by a patient who got tired of scrolling ClinicalTrials.gov

Overview

690
Recruiting
160
Phase 1
330
Phase 2
70
Phase 3
23
Phase 4

Active interventional trials with status RECRUITING or NOT_YET_RECRUITING. A multi-phase trial (e.g. 1/2) is counted in each of its phases.

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Mechanism Breakdown

Recruiting trials grouped by drug class. Trials with unclassifiable or non-therapeutic interventions are excluded from this view.

Checkpoint inhibitor
179
Other / unclassified
58
Bispecific antibody
41
Tyrosine kinase inhibitor (TKI)
29
Chemotherapy
25
Monoclonal antibody
24
CAR-T cellular therapy
23
Other inhibitor
11
Vaccine (other)
9
Antibody-drug conjugate (ADC)
8
TIL cellular therapy
7
Small-molecule inhibitor
6

Recently Updated Trials

NCTPhaseTitleMechanism
NCT076271911GLP-1 RA Plus SOC Treatment in First-line, Metastatic Pancreatic, Colorectal, or Hepatocellular CancerGLP-1 receptor -- receptor agonist (GLP-1 RA)
NCT074198411A Phase 1 Study of the Safety and Tolerability of CTX-10726Unknown mechanism
NCT06728293Effect of the HCC Liver-Link InterventionUnknown mechanism
NCT07628751A Study of Standard Of Care Versus Radio Ablation in Early Stage HCCUnknown mechanism
NCT060661381A Study of Therapeutic Drug Monitoring-Based Atezolizumab DosingPD-L1 -- immune checkpoint inhibitor (atezolizumab)

Top Sponsors

SponsorRecruiting trials
Sun Yat-sen University39
Tianjin Medical University Cancer Institute and Hospital16
Second Affiliated Hospital of Guangzhou Medical University16
Fudan University16
Tongji Hospital13

Geographic Distribution

Countries/regions with the most active trial sites for hepatocellular carcinoma. A multi-site trial is counted once per country/region.

China
318
United States
124
France
42
Taiwan
34
South Korea
33
Italy
21
Germany
19
Hong Kong
17
Spain
15
Canada
14

Emerging Classes

Phase-1 trials whose listed start date falls within the last 12 months — the leading edge of the field.

StartNCTTitleMechanism
Aug 2026NCT07430202A DNAJB1-PRKACA Fusion Kinase Peptide Vaccine Combined With Glutamine Antagonist DRP-104, Nivolumab, and Ipilimumab in Patients With Advanced Stage Fibrolamellar Carcinoma (FLC)DNAJB1-PRKACA fusion kinase -- peptide vaccine plus glutamine antagonist plus PD-1 and CTLA-4 immune checkpoint inhibitors
Jul 1, 2026NCT07365839Cemiplimab +/- Fianlimab Post Y90 Radioembolization in Patients With Hepatocellular CarcinomaPD-1 -- immune checkpoint inhibitor (cemiplimab) +/- CTLA-4 inhibitor (fianlimab)
Jun 30, 2026NCT07627191GLP-1 RA Plus SOC Treatment in First-line, Metastatic Pancreatic, Colorectal, or Hepatocellular CancerGLP-1 receptor -- receptor agonist (GLP-1 RA)
Jun 2026NCT07587034HAIC-TACE Plus Apatinib and Camrelizumab for Liver CancerVEGFR2 -- tyrosine kinase inhibitor (apatinib); PD-1 -- immune checkpoint inhibitor (camrelizumab)
May 29, 2026NCT07583316A Phase 1 First-in-Human Study of CRPA1A2, a MAGE-A1/HLA-A*02:01 Bispecific T-Cell Engager, in Patients With Solid TumorsMAGE-A1 + HLA-A*02:01 -- bispecific T-cell engager
May 1, 2026NCT07446257THIO and Cadonilimab in Resectable Hepatocellular CarcinomaPD-1 + CTLA-4 + nucleoside analog -- immune checkpoint inhibitor plus nucleoside analog
Apr 30, 2026NCT07522411Sequential FOLFOX-HAIC-TACE Plus Sintilimab-Bevacizumab Neoadjuvant Therapy Versus Direct Resection in Resectable High-Risk Recurrence Hepatocellular CarcinomaChemotherapy (FOLFOX) + PD-1 inhibitor + VEGF inhibitor + TACE -- combination therapy
Apr 14, 2026NCT07478302A Study of SHR-2524 Plus Bevacizumab in the First-line Treatment of Advanced Hepatocellular CarcinomaROCK2 -- selective ROCK2 inhibitor plus VEGF -- anti-angiogenic antibody

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Source: ClinicalTrials.gov, synced daily. Aggregated by ClinTrialFinder.