Lung Cancer (NSCLC) Trial Landscape (August 2026)

Last updated: Aug 26, 2026 · Built by a patient who got tired of scrolling ClinicalTrials.gov

Overview

1,322
Recruiting
320
Phase 1
745
Phase 2
199
Phase 3
23
Phase 4

Active interventional trials with status RECRUITING or NOT_YET_RECRUITING. A multi-phase trial (e.g. 1/2) is counted in each of its phases.

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Mechanism Breakdown

Recruiting trials grouped by drug class. Trials with unclassifiable or non-therapeutic interventions are excluded from this view.

Checkpoint inhibitor
243
Tyrosine kinase inhibitor (TKI)
194
Antibody-drug conjugate (ADC)
77
Chemotherapy
62
Other / unclassified
57
Bispecific antibody
53
Other inhibitor
20
Monoclonal antibody
20
Covalent small-molecule inhibitor
18
Vaccine (other)
18
Small-molecule inhibitor
17
TIL cellular therapy
14

Recently Updated Trials

NCTPhaseTitleMechanism
NCT067800982Substudy 01I: A Study of Investigational Agents in Participants With Previously Treated Stage IV Squamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01I/KEYMAKER-U01I)Unknown mechanism
NCT073916701A Phase I Dose Escalation and Dose Expansion Study to Investigate the Pharmacokinetics and Safety of Subcutaneous DurvalumabPD-L1 -- immune checkpoint blockade (monoclonal antibody)
NCT072504772Risk-adapted, Proteomic-guided Systemic Therapy for Previously Untreated Advanced Non-small Cell Lung CancerUnknown mechanism
NCT071000802, 3Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)Trop-2 -- antibody-drug conjugate (izalontamab brengitecan) + platinum-based chemotherapy
NCT073885243Testing the Impact of an Anti-Cancer Drug, Atezolizumab, After Surgery to Prevent Early Stage Non-small Cell Lung Cancer From Returning, AASI-NSCLC TrialPD-L1 -- immune checkpoint inhibitor (atezolizumab) + recombinant human hyaluronidase

Top Sponsors

SponsorRecruiting trials
Sun Yat-sen University33
Tianjin Medical University Cancer Institute and Hospital29
Shanghai Pulmonary Hospital, Shanghai, China29
Hunan Province Tumor Hospital23
Shanghai Chest Hospital22

Geographic Distribution

Countries/regions with the most active trial sites for lung cancer (nsclc). A multi-site trial is counted once per country/region.

China
602
United States
376
France
127
Spain
125
Italy
111
Canada
97
South Korea
93
Australia
92
Germany
86
Japan
85

Emerging Classes

Phase-1 trials whose listed start date falls within the last 12 months — the leading edge of the field.

StartNCTTitleMechanism
Dec 1, 2026NCT066381253-Dimensional Virtual Reality Modelling With Intravascular Indocyanine Green Fluorescence Mapping for Targeted Pulmonary Segmental Resection TrialIndocyanine green -- fluorescent dye for surgical navigation
Nov 30, 2026NCT07579221Ph1/2 Trial Of Navlimetostat With Pumitamig In MTAP-Deficient Advanced Non-Small Cell Lung CancerEZH2 + PRMT5 -- epigenetic enzyme inhibitors
Oct 30, 2026NCT07272642A Phase 1, Multicenter Imaging Study of LNTH-2403 in Participants With Locally Advanced or Metastatic Solid Tumors.LRRC15 -- radiolabeled monoclonal antibody (radioimmunotherapy)
Sep 14, 2026NCT07619599A PET Imaging Agent (64Cu-DOTA-Pembrolizumab) for Determining Treatment Response Among Patients With Stage IV Non-small Cell Lung Cancer Receiving PembrolizumabPD-1 -- antibody (immune checkpoint inhibitor)
Sep 7, 2026NCT07436858Whole Body HER2 Quantification With 89Zr-Trastuzumab PET/CT to Asses Zr-trastuzumab Accumulation in HER2-mutated and HER2-overexpressing Metastatic Non-small Cell Lung CancerHER2 -- radiolabeled antibody for PET imaging (diagnostic antibody)
Aug 17, 2026NCT07784959Study of NXP900 With Lorlatinib in ALK+ Lung CancerALK -- tyrosine kinase inhibitor (TKI) (Lorlatinib); Unknown mechanism (NXP900)
Aug 2026NCT07594067TCR1188-ABC Cells in KRAS-mutated CancersKRAS mutant peptides -- T cell receptor (TCR) engineered T cells
Aug 2026NCT07675876Inhaled Cromolyn Sodium in Patients With Locally Advanced Lung CancerMast cell stabilization -- inhibition of mast cell degranulation (mast cell stabilizer)

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Source: ClinicalTrials.gov, synced daily. Aggregated by ClinTrialFinder.