Lung Cancer (NSCLC) Trial Landscape (October 2026)

Last updated: Oct 15, 2026 · Built by a patient who got tired of scrolling ClinicalTrials.gov

Overview

1,330
Recruiting
310
Phase 1
750
Phase 2
202
Phase 3
24
Phase 4

Active interventional trials with status RECRUITING or NOT_YET_RECRUITING. A multi-phase trial (e.g. 1/2) is counted in each of its phases.

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Mechanism Breakdown

Recruiting trials grouped by drug class. Trials with unclassifiable or non-therapeutic interventions are excluded from this view.

Checkpoint inhibitor
243
Tyrosine kinase inhibitor (TKI)
195
Antibody-drug conjugate (ADC)
80
Chemotherapy
57
Bispecific antibody
56
Other / unclassified
53
Other inhibitor
20
Covalent small-molecule inhibitor
19
Monoclonal antibody
18
Vaccine (other)
18
Small-molecule inhibitor
17
TIL cellular therapy
15

Recently Updated Trials

NCTPhaseTitleMechanism
NCT071051761HS-IT101 Injection for Advanced NSCLC(FASTIL-Lung01)Unknown mechanism
NCT042678483Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])PD-1 -- immune checkpoint inhibitor (monoclonal antibody)
NCT071859973Study to Evaluate Efficacy and Safety of Firmonertinib Compared With Investigator's Choice of EGFR Inhibitor as First-Line Treatment in Participants Who Have Locally Advanced or Metastatic NSCLC With EGFR P-Loop and Alpha C-Helix Compressing (PACC) Uncommon MutationsEGFR PACC uncommon mutations -- EGFR tyrosine kinase inhibitor (TKI)
NCT069317173A Clinical Study to Assess the Efficacy of Adjuvant Immunotherapy With Cemiplimab in Patients With Surgically Removed Non-small Cell Lung Cancer Who Have Not Received Prior ChemotherapyPD-1 -- immune checkpoint inhibitor
NCT074623771A Phase 1 Study of EPI-326 in EGFR-mutant NSCLC and HNSCCUnknown mechanism

Top Sponsors

SponsorRecruiting trials
Sun Yat-sen University33
Shanghai Pulmonary Hospital, Shanghai, China31
Tianjin Medical University Cancer Institute and Hospital28
Shanghai Chest Hospital22
Fudan University21

Geographic Distribution

Countries/regions with the most active trial sites for lung cancer (nsclc). A multi-site trial is counted once per country/region.

China
606
United States
373
France
127
Spain
125
Italy
109
Canada
95
Australia
95
South Korea
92
Japan
87
Taiwan
84

Emerging Classes

Phase-1 trials whose listed start date falls within the last 12 months — the leading edge of the field.

StartNCTTitleMechanism
Dec 1, 2027NCT05745740A Study of RC48-ADC Combined With Pyrotinib For Treatment of Local Advanced or Metastasis NSCLC With HER2 MutationHER2 -- antibody-drug conjugate (ADC) + tyrosine kinase inhibitor (TKI)
Dec 1, 2026NCT066381253-Dimensional Virtual Reality Modelling With Intravascular Indocyanine Green Fluorescence Mapping for Targeted Pulmonary Segmental Resection TrialIndocyanine green -- fluorescent dye for surgical navigation
Dec 2026NCT07594067TCR1188-ABC Cells in KRAS-mutated CancersKRAS mutant peptides -- T cell receptor (TCR) engineered T cells
Oct 30, 2026NCT07272642A Phase 1, Multicenter Imaging Study of LNTH-2403 in Participants With Locally Advanced or Metastatic Solid Tumors.LRRC15 -- radiolabeled monoclonal antibody (radioimmunotherapy)
Oct 1, 2026NCT07842887Phase 1 Study of ATRA Plus a PD-1 Inhibitor in EGFR-Mutant NSCLC After Third-Generation EGFR-TKI ResistancePD-1 -- immune checkpoint inhibitor (monoclonal antibody); Retinoic acid receptor -- differentiation inducer (small molecule)
Sep 28, 2026NCT07798921JIN-A02 Plus Amivantamab in EGFR-Mutant NSCLC After Third-Generation EGFR-TKI FailureEGFR + MET -- bispecific antibody (Amivantamab) combined with unknown mechanism (JIN-A02)
Sep 21, 2026NCT07830342A Clinical Study of HS-IT101 Injection in Patients With Advanced Non-Small Cell Lung Cancer(FASTIL-Lung02)Tumor-infiltrating lymphocytes (TILs) -- adoptive cell therapy
Sep 14, 2026NCT07619599A PET Imaging Agent (64Cu-DOTA-Pembrolizumab) for Determining Treatment Response Among Patients With Stage IV Non-small Cell Lung Cancer Receiving PembrolizumabPD-1 -- antibody (immune checkpoint inhibitor)

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Source: ClinicalTrials.gov, synced daily. Aggregated by ClinTrialFinder.