Melanoma Trial Landscape (May 2026)

Last updated: May 28, 2026 · Built by a patient who got tired of scrolling ClinicalTrials.gov

Overview

358
Recruiting
126
Phase 1
165
Phase 2
39
Phase 3
6
Phase 4

Active interventional trials with status RECRUITING or NOT_YET_RECRUITING. A multi-phase trial (e.g. 1/2) is counted in each of its phases.

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Mechanism Breakdown

Recruiting trials grouped by drug class. Trials with unclassifiable or non-therapeutic interventions are excluded from this view.

Checkpoint inhibitor
93
Other / unclassified
22
TIL cellular therapy
22
Bispecific antibody
20
Monoclonal antibody
10
Vaccine (other)
9
Small-molecule inhibitor
8
Other inhibitor
7
Kinase inhibitor (other)
6
Tyrosine kinase inhibitor (TKI)
5
CAR-T cellular therapy
5
Oncolytic virus
4

Recently Updated Trials

NCTPhaseTitleMechanism
NCT03941756Lymphovenous Bypass Procedure Before Underarm Lymph Node Surgery in Preventing Lymphedema in Patients With Inflammatory or Locally Advanced Non-inflammatory Breast Cancer or MelanomaUnknown mechanism
NCT060661381A Study of Therapeutic Drug Monitoring-Based Atezolizumab DosingPD-L1 -- immune checkpoint inhibitor (atezolizumab)
NCT05053555High Dose-Rate Brachytherapy for the Treatment of Both Primary and Secondary Unresectable Liver MalignanciesUnknown mechanism
NCT054987921Study of CBL0137 in Combination With Ipilimumab and Nivolumab Therapy in MelanomaFACT complex modulator CBL0137 + CTLA-4 + PD-1 -- small molecule + immune checkpoint inhibitors
NCT05225428Video Education With Result Dependent dIsclosureUnknown mechanism

Top Sponsors

SponsorRecruiting trials
M.D. Anderson Cancer Center18
H. Lee Moffitt Cancer Center and Research Institute8
Vastra Gotaland Region7
National Cancer Institute (NCI)7
Xijing Hospital5

Geographic Distribution

Countries/regions with the most active trial sites for melanoma. A multi-site trial is counted once per country/region.

United States
158
China
50
Australia
31
France
28
Netherlands
23
Canada
23
United Kingdom
21
Germany
21
Spain
20
Italy
20

Emerging Classes

Phase-1 trials whose listed start date falls within the last 12 months — the leading edge of the field.

StartNCTTitleMechanism
Aug 31, 2026NCT07444606Dose Ranging, Toxicity Seeking, Phase 1 Trial of Oncolytic Adenoviral Therapy for Melanoma Intracranial and Extracranial MetastasesOncolytic adenovirus -- oncolytic viral therapy (DNX-2401)
Aug 31, 2026NCT07414979Phase 1 Study Of Intrathecal Cellular Adoptive Immunotherapy Using Autologous CD8+ Antigen-Specific T Cells For Patients With Leptomeningeal MelanomaTumor antigens -- adoptive CD8+ antigen-specific T cell therapy
Aug 1, 2026NCT07581509Pharmacokinetics, Safety, and Immunogenicity of Bmab1800 and Keytruda® as Adjuvant Monotherapy in Patients With MelanomaPD-1 -- immune checkpoint inhibition (monoclonal antibody)
Jun 30, 2026NCT07518043A Study of HLX18 vs. OPDIVO® in Multiple Resected Solid TumorsPD-1 -- immune checkpoint inhibitor biosimilar (monoclonal antibody)
Jun 19, 2026NCT07475572A Randomized, Double-Blind, Pharmacokinetic Similarity Study to Compare AVT32-DRL_PB With Keytruda® in Participants With Fully Resected MelanomaPD-1 -- immune checkpoint inhibitor (monoclonal antibody biosimilar)
Jun 1, 2026NCT07476326Pharmacokinetics, Safety, and Immunogenicity Comparison of Bmab1700 and Opdivo® as Adjuvant Monotherapy in Participants With MelanomaPD-1 -- immune checkpoint inhibitor (nivolumab biosimilar Bmab1700 and Opdivo)
Jun 2026NCT07389525Immune Checkpoint Inhibitor (ICI)-Drug-Drug Interaction (DDI) StudyImmune checkpoint inhibitors -- immune checkpoint blockade (monoclonal antibodies)
May 1, 2026NCT07237594IL-17 Blockade to Decrease irAEs (REPLAY)IL-17A -- monoclonal antibody (Secukinumab)

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Source: ClinicalTrials.gov, synced daily. Aggregated by ClinTrialFinder.