Mesothelioma Clinical Trials (April 2026): 70 Recruiting Interventional Studies
Last updated: April 18, 2026
Current Clinical Trial Landscape
Active research areas in 2026:
- Checkpoint inhibitor combinations (19 trials)
- Mesothelin-targeted therapies incl. CAR-T (6 trials)
- Surgery + immunotherapy combinations (13 trials)
Standard of care: Unresectable: nivolumab + ipilimumab (CheckMate 743) or pemetrexed + platinum + bevacizumab. Resectable: surgery + chemotherapy.
Recruiting Trials by Treatment Setting
Unresectable / Advanced Mesothelioma
First-line and beyond for patients not eligible for surgery:
- Checkpoint + TKI combinations:
- NCT06318286 - Pembrolizumab + chemotherapy + Lenvatinib
- NCT05188859 - Sintilimab + Anlotinib + platinum doublet
- NCT06543069 - Sintilimab + Bevacizumab + Pemetrexed/Cisplatin
- Novel immunotherapy:
- NCT04400539 - 5-ALA photodynamic therapy + immunotherapy
Resectable / Surgery Combinations
Neoadjuvant and adjuvant immunotherapy with surgery:
- NCT05932199 - Neoadjuvant Durvalumab + Tremelimumab ± chemotherapy
- NCT03760575 - Pembrolizumab + chemotherapy + image-guided surgery
- NCT05647265 - Immunotherapy before surgery (sarcomatoid subtype)
- NCT07121374 - Neoadjuvant chemo-immunotherapy for selected inoperable cases
Peritoneal Mesothelioma
Trials specifically for peritoneal disease:
Trials by Treatment Approach
Checkpoint Inhibitors (19 trials)
PD-1/PD-L1 and CTLA-4 inhibitors, often combined with chemotherapy or targeted agents. View all →
Mesothelin-Targeted Therapies (6 trials)
CAR-T cells, antibody-drug conjugates, and other therapies targeting mesothelin, highly expressed in mesothelioma. View all →
- NCT06885697 - Anti-Mesothelin CAR T cells
- NCT06051695 - Logic-gated mesothelin CAR-T
- NCT05568680 - SynKIR-110 for mesothelin-expressing tumors
- NCT06097728 - MEDI5752 + carboplatin + pemetrexed in unresectable pleural mesothelioma (Phase 3)
- NCT07510815 - Dual-target MSLN/FAP CAR-NK cells for pleural and peritoneal mesothelioma (Phase 1/2)
Surgery Combinations (13 trials)
Pleurectomy/decortication or extrapleural pneumonectomy combined with systemic therapy. View all →
Frequently Asked Questions
How do I find mesothelioma clinical trials I'm eligible for?
Paste your medical summary into ClinTrialFinder to get AI-matched mesothelioma trials in minutes. The tool considers your mesothelioma subtype (pleural vs peritoneal), stage, and prior treatments.
What mesothelioma trials are currently recruiting?
There are 70 recruiting interventional trials for mesothelioma including immunotherapy (PD-1/PD-L1 inhibitors), CAR-T cell therapy, and novel agents for both pleural and peritoneal mesothelioma.
Find Mesothelioma Trials Matched to Your Situation
Use ClinTrialFinder's AI-powered matching to find trials based on your specific condition.
Find Matching Trials
