Mesothelioma Clinical Trials (May 2026): 73 Recruiting Interventional Studies
Last updated: May 17, 2026
Current Clinical Trial Landscape
Active research areas in 2026:
- Checkpoint inhibitor combinations — nivo+ipi backbone with TKIs (lenvatinib, anlotinib) or anti-VEGF (bevacizumab)
- Mesothelin-targeted therapies including CAR-T cells and logic-gated / dual-target CAR-NK
- Antibody-drug conjugates — sacituzumab govitecan (Trodelvy, TROP2) Phase 2 expansion into mesothelioma, brentuximab vedotin in the CD30-expressing subset
- Surgery + immunotherapy combinations — neoadjuvant nivo+ipi or pembro+chemo before pleurectomy
- Peritoneal-mesothelioma-specific systemic therapy trials (chemo ± immunotherapy)
- PD-1/CTLA-4 bispecific antibodies (MEDI5752) + chemotherapy — Phase 3
Standard of care: Unresectable: nivolumab + ipilimumab (CheckMate 743) or pemetrexed + platinum + bevacizumab. Resectable: surgery + chemotherapy.
Recruiting Trials by Treatment Setting
Unresectable / Advanced Mesothelioma
First-line and beyond for patients not eligible for surgery:
- Checkpoint + TKI combinations:
- NCT06318286 - Pembrolizumab + chemotherapy + Lenvatinib
- NCT05188859 - Sintilimab + Anlotinib + platinum doublet
- NCT06543069 - Sintilimab + Bevacizumab + Pemetrexed/Cisplatin
- Novel immunotherapy:
- NCT04400539 - 5-ALA photodynamic therapy + immunotherapy
Resectable / Surgery Combinations
Neoadjuvant and adjuvant immunotherapy with surgery:
- NCT05932199 - Neoadjuvant Durvalumab + Tremelimumab ± chemotherapy
- NCT03760575 - Pembrolizumab + chemotherapy + image-guided surgery
- NCT05647265 - Immunotherapy before surgery (sarcomatoid subtype)
- NCT07121374 - Neoadjuvant chemo-immunotherapy for selected inoperable cases
Peritoneal Mesothelioma
Trials specifically for peritoneal disease:
- NCT06057935 - Additional chemotherapy after surgery
- NCT05001880 - Chemotherapy ± immunotherapy for peritoneal mesothelioma (Phase 2)
Trials by Treatment Approach
Checkpoint Inhibitors (19 trials)
PD-1/PD-L1 and CTLA-4 inhibitors, often combined with chemotherapy or targeted agents. View all →
Mesothelin-Targeted Therapies (6 trials)
CAR-T cells, antibody-drug conjugates, and other therapies targeting mesothelin, highly expressed in mesothelioma. View all →
- NCT06885697 - Anti-Mesothelin CAR T cells
- NCT06051695 - Logic-gated mesothelin CAR-T
- NCT05568680 - SynKIR-110 for mesothelin-expressing tumors
- NCT06097728 - MEDI5752 + carboplatin + pemetrexed in unresectable pleural mesothelioma (Phase 3)
- NCT07510815 - Dual-target MSLN/FAP CAR-NK cells for pleural and peritoneal mesothelioma (Phase 1/2)
Surgery Combinations (13 trials)
Pleurectomy/decortication or extrapleural pneumonectomy combined with systemic therapy. View all →
Antibody-Drug Conjugates
Two ADC trials specifically open to mesothelioma patients. Both require specific eligibility — ask about IHC testing on archival biopsy:
- NCT06477419 - Sacituzumab govitecan (Trodelvy, TROP2 ADC) in mesothelioma (Phase 2). Already FDA-approved for triple-negative breast cancer and HR+ breast cancer; this study tests it in mesothelioma.
- NCT03007030 - Brentuximab vedotin in CD30+ malignant mesothelioma (Phase 2). Requires CD30 positivity by IHC — not all mesothelioma expresses CD30, so testing first.
Frequently Asked Questions
How do I find mesothelioma clinical trials I'm eligible for?
Paste your medical summary into ClinTrialFinder to get AI-matched mesothelioma trials in minutes. The tool considers your mesothelioma subtype (pleural vs peritoneal), stage, and prior treatments.
What mesothelioma trials are currently recruiting?
There are 73 recruiting interventional trials for mesothelioma including checkpoint inhibitor combinations with TKIs (lenvatinib, anlotinib) and anti-VEGF (bevacizumab), mesothelin-targeted CAR-T and logic-gated CAR-NK cell therapy, antibody-drug conjugates (sacituzumab govitecan / Trodelvy for TROP2, brentuximab vedotin for CD30+), PD-1/CTLA-4 bispecific antibodies (MEDI5752) with chemotherapy, and surgery + immunotherapy combinations for both pleural and peritoneal mesothelioma.
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