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25 Gallbladder Cancer Clinical Trials Recruiting Now (July 2026): Biliary Tract, HER2 Zanidatamab T-DXd, Nanvuranlat, Durvalumab

Last updated: July 1, 2026

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Current Clinical Trial Landscape

About gallbladder cancer:

Gallbladder cancer is a rare but aggressive biliary tract cancer. Often diagnosed at advanced stages due to vague symptoms. Treatment options are limited, making clinical trials particularly important.

Active research areas in 2026:

Standard of care: Resectable: surgery + adjuvant capecitabine. Unresectable/metastatic: gemcitabine + cisplatin ± durvalumab (TOPAZ-1).

Recruiting Trials by Treatment Setting

Neoadjuvant Therapy

Before surgery for locally advanced disease:

First-Line Metastatic/Unresectable

For previously untreated advanced disease:

Molecular-Targeted Maintenance

Targeted maintenance after first-line chemotherapy, guided by tumor molecular profile:

Second-Line and Beyond

After progression on first-line therapy:

Trials by Treatment Approach

Immunotherapy Combinations

Checkpoint inhibitors with chemotherapy or other agents:

HER2-Targeted Therapy

For HER2-positive gallbladder cancer (~15-20%):

KRAS-Targeted Therapy

Regional Therapies

Hepatic arterial infusion and radiation:

Novel Targeted Agents

View all 32 gallbladder cancer trials on ClinicalTrials.gov →

Frequently Asked Questions

How do I find gallbladder cancer clinical trials?

Paste your medical summary into ClinTrialFinder to get AI-matched gallbladder and biliary tract cancer trials in minutes. The tool considers your HER2 expression, MSI status, FGFR alterations, and treatment history.

What gallbladder cancer trials are currently recruiting?

There are 25 recruiting interventional trials for gallbladder cancer in July 2026 (strict gallbladder-specific filter; the broader biliary-tract overlap brings the practical count closer to the prior 32) including 5 Phase 3 studies. Recent Phase 3: ARTEMIDE-Biliary02 rilvegostomig vs durvalumab + chemo BTC NCT07221253, nanvuranlat NCT07265674, zanidatamab + SOC vs SOC NCT06282575. Active classes: immunotherapy combinations, HER2-targeted therapies (T-DXd + rilvegostomig NCT06467357 — see HER2 ADCs hub), and novel agents for gallbladder and biliary tract cancers.

Find Gallbladder Cancer Trials Matched to Your Situation

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This page is for information only and is not medical advice. ClinTrialFinder helps you find clinical trials that may match your situation, but enrollment decisions and treatment choices should always be made with your oncologist or healthcare team. Trial eligibility, recruitment status, and treatment details can change — verify directly with the trial sponsor or on ClinicalTrials.gov before acting on any information here.