Gallbladder Cancer Clinical Trials (April 2026): 32 Recruiting Interventional Studies
Last updated: April 19, 2026
Current Clinical Trial Landscape
About gallbladder cancer:
Gallbladder cancer is a rare but aggressive biliary tract cancer. Often diagnosed at advanced stages due to vague symptoms. Treatment options are limited, making clinical trials particularly important.
Active research areas in 2026:
- Immunotherapy combinations (checkpoint inhibitors + chemo)
- HER2-targeted therapy (~15-20% HER2+ gallbladder cancers)
- Neoadjuvant chemotherapy for locally advanced disease
- Hepatic arterial infusion chemotherapy (HAIC)
Standard of care: Resectable: surgery + adjuvant capecitabine. Unresectable/metastatic: gemcitabine + cisplatin ± durvalumab (TOPAZ-1).
Recruiting Trials by Treatment Setting
Neoadjuvant Therapy
Before surgery for locally advanced disease:
- NCT06712420 - Neoadjuvant chemotherapy for locally advanced gallbladder cancer (Phase 3)
First-Line Metastatic/Unresectable
For previously untreated advanced disease:
- NCT07221253 - Rilvegostomig or durvalumab + chemotherapy (Phase 3)
- NCT07265674 - Novel combination vs standard of care (Phase 3)
- NCT06529718 - Ivonescimab vs FOLFOX (Phase 2)
Second-Line and Beyond
After progression on first-line therapy:
- NCT07146646 - Trifluridine/tipiracil + oxaliplatin (Phase 2)
- NCT07025174 - Sequential anti-angiogenic therapy after immunotherapy
Trials by Treatment Approach
Immunotherapy Combinations
Checkpoint inhibitors with chemotherapy or other agents:
- NCT06423170 - Camrelizumab combination (Phase 2)
- NCT05757336 - Gemcitabine + albumin-paclitaxel + sintilimab + bevacizumab
HER2-Targeted Therapy
For HER2-positive gallbladder cancer (~15-20%):
- NCT06282575 - Zanidatamab + standard of care (Phase 3)
- NCT05786716 - Trastuzumab + pertuzumab (DETERMINE Trial)
KRAS-Targeted Therapy
- NCT07023731 - ARV-806 for KRAS G12D mutations (Phase 1/2)
Regional Therapies
Hepatic arterial infusion and radiation:
- NCT06852287 - GemOX hepatic arterial infusion + lenvatinib + PD-1 (Phase 2)
- NCT06214572 - Radiation therapy in unresectable gallbladder cancer
Novel Targeted Agents
View all 32 gallbladder cancer trials on ClinicalTrials.gov →
Frequently Asked Questions
How do I find gallbladder cancer clinical trials?
Paste your medical summary into ClinTrialFinder to get AI-matched gallbladder and biliary tract cancer trials in minutes. The tool considers your HER2 expression, MSI status, FGFR alterations, and treatment history.
What gallbladder cancer trials are currently recruiting?
There are 32 recruiting interventional trials for gallbladder cancer including immunotherapy, HER2-targeted therapies, and novel agents for gallbladder and biliary tract cancers.
Find Gallbladder Cancer Trials Matched to Your Situation
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